The Saint John Sea Dogs have seen 23 players go on to play at least one game in the National Hockey League in their history. Defenceman Yann Sauve became the first Sea Dog to appear in the NHL when he suited up for the Vancouver Canucks on February 15, 2011.
| PLAYER | SEA DOGS CAREER | NHL DEBUT TEAM | OTHER NHL TEAMS | FIRST NHL GAME |
| Yann Sauve | 2006-2010 | Vancouver Canucks | — | February 15, 2011 vs MIN |
| Simon Despres | 2007-2011 | Pittsburgh Penguins | ANA | December 1, 2011 @ WAS |
| Mike Hoffman | 2009-2010 | Ottawa Senators | FLA, STL, MTL, SJS | December 23, 2011 @ CAR |
| Jonathan Huberdeau | 2009-2013 | Florida Panthers | CGY | January 19, 2013 vs CAR |
| Charlie Coyle | 2011-2012 | Minnesota Wild | BOS, COL, CBJ | February 4, 2013 vs AZ |
| Nathan Beaulieu | 2008-2012 | Montreal Canadiens | BUF, WPG, ANA | March 30, 2013 vs NYR |
| Eric Gelinas | 2010-2011 | New Jersey Devils | COL | April 25, 2013 vs PIT |
| Alex Grant | 2005-2009 | Anaheim Ducks | ARI | November 30, 2013 vs SJS |
| Tomas Jurco | 2009-2012 | Detroit Red Wings | CHI, EDM, VGK | December 15, 2013 vs TBL |
| Brett Gallant | 2005-2008 | New York Islanders | — | April 8, 2014 vs OTT |
| Stanislav Galiev | 2009-2012 | Washington Capitals | — | April 8, 2015 vs BOS |
| Thomas Chabot | 2013-2017 | Ottawa Senators | — | October 18, 2016 vs AZ |
| Christopher DiDomenico | 2006-2009 | Ottawa Senators | — | March 9, 2017 @ AZ |
| Matthew Highmore | 2012-2017 | Chicago Blackhawks | VAN, STL, OTT | March 1, 2018 @ SJS |
| Mathieu Joseph | 2013-2017 | Tampa Bay Lightning | OTT, STL, LAK | October 6, 2018 vs FLA |
| Jakub Zboril | 2014-2017 | Boston Bruins | — | November 18, 2018 @ DAL |
| Julien Gauthier | 2016-2017 | Carolina Hurricanes | NYR, OTT, NYI | October 11, 2019 vs NYI |
| Joe Veleno | 2015-2018 | Detroit Red Wings | CHI, MTL | April 27, 2021 @ CBJ |
| Boko Imama | 2014-2017 | Arizona Coyotes | OTT, PIT | April 22, 2022 vs WAS |
| William Dufour | 2021-2022 | New York Islanders | — | January 18, 2023 vs BOS |
| Yan Kuznetsov | 2021-2022 | Calgary Flames | — | January 9, 2024 vs OTT |
| William Villeneuve | 2018-2022 | Toronto Maple Leafs | — | April 11, 2026 vs FLA |
NHL Drafted Players
The Sea Dogs have had 33 players hear their names called at the NHL Draft. Of those players, the first to be drafted into the NHL was defenceman Felix Schutz who was selected in the fourth round, 117th overall by the Buffalo Sabres in 2006.
The year in which the highest number of Sea Dogs were drafted was 2015 when seven players were selected. Seven players have been chosen in the first round of the NHL Draft.
| YEAR | PLAYER | POSITION | ROUND | OVERALL | TEAM |
| 2006 | Felix Schutz | D | 4 | 117 | Buffalo Sabres |
| 2007 | Alex Grant | D | 4 | 118 | Pittsburgh Penguins |
| Christopher DiDomenico | F | 6 | 164 | Toronto Maple Leafs | |
| 2008 | Yann Sauve | D | 2 | 41 | Vancouver Canucks |
| 2009 | Simon Despres | D | 1 | 30 | Pittsburgh Penguins |
| Steven Anthony | F | 7 | 187 | Vancouver Canucks | |
| 2010 | Stanislav Galiev | F | 3 | 86 | Washington Capitals |
| Mike Hoffman | F | 5 | 130 | Ottawa Senators | |
| Stephen MacAulay | F | 6 | 164 | St. Louis Blues | |
| 2011 | Jonathan Huberdeau | F | 1 | 3 | Florida Panthers |
| Nathan Beaulieu | D | 1 | 17 | Montreal Canadiens | |
| Zack Phillips | F | 1 | 28 | Minnesota Wild | |
| Tomas Jurco | F | 2 | 35 | Detroit Red Wings | |
| Ryan Tesink | F | 6 | 162 | St. Louis Blues | |
| 2014 | Olivier Leblanc | D | 7 | 197 | Columbus Blue Jackets |
| 2015 | Jakub Zboril | D | 1 | 13 | Boston Bruins |
| Thomas Chabot | D | 1 | 18 | Ottawa Senators | |
| Samuel Dove-McFalls | F | 4 | 98 | Philadelphia Flyers | |
| Mathieu Joseph | F | 4 | 120 | Tampa Bay Lightning | |
| Spencer Smallman | F | 5 | 138 | Carolina Hurricanes | |
| Bokondji Imama | F | 6 | 180 | Tampa Bay Lightning | |
| Adam Marsh | F | 7 | 200 | Detroit Red Wings | |
| 2016 | Luke Green | D | 3 | 79 | Winnipeg Jets |
| Nathan Noel | F | 4 | 113 | Chicago Blackhawks | |
| 2017 | Cedric Pare | F | 6 | 173 | Boston Bruins |
| 2018 | Joe Veleno | F | 1 | 30 | Detroit Red Wings |
| Radim Salda | D | 7 | 206 | Tampa Bay Lightning | |
| 2019 | Maxim Cajkovic | F | 3 | 89 | Tampa Bay Lightning |
| 2020 | Jeremie Poirier | D | 3 | 72 | Calgary Flames |
| William Villeneuve | D | 4 | 122 | Toronto Maple Leafs | |
| 2021 | Cameron MacDonald | F | 5 | 160 | Tampa Bay Lightning |
| 2024 | Eriks Mateiko | F | 3 | 90 | Washington Capitals |
| 2026 | Olivers Murnieks | F | 4 | 124 | Buffalo Sabres |